The U.S. Department of Energy has signed agreements with 24 organizations, including Microsoft, Google, Nvidia, Amazon Web Services, IBM, Intel, Oracle, and OpenAI, to advance its Genesis Mission. The initiative seeks to apply artificial intelligence to speed scientific discovery and bolster U.S. energy and security capabilities. It aims to lift scientific productivity and curb dependence on foreign technology. Partners will build AI models for nuclear energy, quantum computing, robotics, and supply chain optimization. The effort follows a White House executive order directing AI deployment in energy innovation, advanced manufacturing, and national security. It extends prior DOE work with industry on high-performance computing at Argonne and Los Alamos labs. The department plans wider ties with universities and non-profits.